Effect of Systemic Administration of Granulocyte-Colony Stimulating Factor on Rate of Fracture Healing of Bone Defect in Goats as Animal Model

Granulocyte-colony stimulating factor (G-CSF) serves as an important cytokine in haematopoiesis; released at both physiological and pathological conditions by a range of cells. We hypothesized that the systemic administration G-CSF would produce accelerated fracture-healing rate non-union bone defects; thus, potentially leading to useful clinical applications. Ten male adult Katjang goats, weighing about 15-26 kilograms were randomly chosen tibial defect was induced each animal. The maintained internal fixation with titanium plate reinforced external fiberglass cast. Post-operative radiographs performed twice weekly radiographic assessments evaluating bridging union measurements through validated method. In treatment group, time for exhibited statistically significant differences when compared control group. outcomes present study establishing notion besides inducing haematopoiesis, promotes healing fractures defects well.